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KMID : 0378019890320100101
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New Medical Journal
1989 Volume.32 No. 10 p.101 ~ p.105
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Efficacy and Safety of Cefuroxime Axetil in the Treatment of Lower Reapiratory Tract Infections
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Abstract
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Cefuroxime axetil, an ester of cefuroxime for oral administration, was evaluated for the treatment of lower respiratory infections. Thirty one patients received 250mg or 500mg of cefuroxime axetil orally twice a day for 7 days.
Of these patients, 70% were female with a mean age of 61.3 years ; 70% had ac to bronchitis and the remainder an acute exacerbation of chronic bronchitis.
Overall, 30 of 31 pateints were clinically cured or improved. The failed case w, s found to have bronchial asthma with bronchitis later. Overall bacteriological cure occurred in 100% of 10 patients with positive sputum culture. Adverse clinical side effect included a facial rash and sleepiness : thrombocytosis was noted in one of 31 patients without clinical adverse effects. From this study, we conclude that cefuroxime axetil given twice a day is clinicallyy very efficacious in the management of lower respiratory tract infection at the out-patie t clinic ; it is a new oral cephalosporin with pharmacologic and bacterial spectrum advantage over many other agents.
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